Thyroglobulin
Large glycoprotein (MW 670K) produced by thyroid follicular cells; later iodinated to form T3 and T4
Specific marker of thyroid differentiation
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TTF-1, Thyroid transcription factor
Interpretation: nuclear stain
Uses: primary vs. metastatic lung carcinoma, pleural lung carcinoma vs. mesothelioma, pulmonary small cell carcinoma vs. Merkel cell carcinoma
Positive staining (normal): lung type II pneumocytes and Clara cells, thyroid follicular and parafollicular C cells
Positive staining (disease):
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Uroplakin III
Transmembrane protein expressed by urothelial lining cells; specific but only 50% sensitive for urothelial lesions (AJSP 2003;27:1)
Negative staining: small cell carcinoma of urinary bladder
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Vimentin
Intermediate filament for mesenchymal tissue
Widespread immunoreactivity
Positive staining (normal): endothelial cells, fibroblasts, vascular smooth muscle
Positive staining (disease): mesenchymal tumors, renal cell carcinoma
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WT1
Tumor suppressor gene at 11p13
Protein is transcriptional regulator that apparently inhibits transcription of growth promoting genes
Involved in development of tissues from inner layer of intermediate mesoderm
Interpretation: nuclear stain
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