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TdT, Terminal deoxynucleotidyl transferase
Terminal deoxynucleotidyl transferase also called terminal transferase
Nuclear DNA polymerase in thymic and small number of bone marrow cortical lymphocytes
Catalyzes addition of deoxynucleotides to 3' OH ends of oligonucleotides or polydeoxynucleotides
Used during immunoglobulin and T cell receptor rearrangement
Interpretation: Nuclear stain
Favorable prognosis for CML in blast crisis
Positive staining (normal): B and T cell precursors, cortical thymocytes
Positive staining (disease): acute lymphoblastic lymphoma (95%, diffuse strong), AML (5-10%, weak, focal)
Negative staining: Myeloid cells, Burkitt’s lymphoma, sarcomas
Terminal deoxynucleotidyl transferase also called terminal transferase
Nuclear DNA polymerase in thymic and small number of bone marrow cortical lymphocytes
Catalyzes addition of deoxynucleotides to 3' OH ends of oligonucleotides or polydeoxynucleotides
Used during immunoglobulin and T cell receptor rearrangement
Interpretation: Nuclear stain
Favorable prognosis for CML in blast crisis
Positive staining (normal): B and T cell precursors, cortical thymocytes
Positive staining (disease): acute lymphoblastic lymphoma (95%, diffuse strong), AML (5-10%, weak, focal)
Negative staining: Myeloid cells, Burkitt’s lymphoma, sarcomas
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