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Synaptophysin
Transmembrane glycoprotein isolated from neuronal presynaptic vesicles
Specific but not sensitive for neuroendocrine tumors; more sensitive in well differentiated tumors
Granular cytoplasmic pattern in small cell carcinoma reflects neurosecretory granules
Positive staining (normal): neuronal cells, neuroendocrine cells
Positive staining (disease): central neurocytoma, neuroendocrine cells/tumors (pheochromocytoma, medullary thyroid carcinoma, pancreatic endocrine tumors, carcinoid tumors)
Transmembrane glycoprotein isolated from neuronal presynaptic vesicles
Specific but not sensitive for neuroendocrine tumors; more sensitive in well differentiated tumors
Granular cytoplasmic pattern in small cell carcinoma reflects neurosecretory granules
Positive staining (normal): neuronal cells, neuroendocrine cells
Positive staining (disease): central neurocytoma, neuroendocrine cells/tumors (pheochromocytoma, medullary thyroid carcinoma, pancreatic endocrine tumors, carcinoid tumors)
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