cne21th

Papillary hyperplasia

Seen in untreated autoimmune hyperthyroidism (Graves disease), congenital errors of thyroid metabolism, and hyperfunctioning foci in goitrous glands.
Toxic nodular goiter, the changes are similar but the lesion tends to be focal.

Papillary Hyperplasia in Follicular Nodule
Well-circumscribed solitary thyroid nodules may show a microscopic appearance of papillary growth.
Papillae contain extremely edematous stalks with follicles.
Nuclei are round and not clear;
No psammoma bodies.