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MPO, Myeloperoxidase
Enzyme cytochemistry for myeloperoxidase (not immunohistochemistry) is the most sensitive and specific stain for myeloid leukemias and granulocytic sarcoma
Stains neutrophils strongly (diffuse granular pattern), other granulocytes variably
Positive staining (enzyme cytochemistry): neutrophils, eosinophils, monocytes (variable), AML-M1, M2, microgranular M3
Positive staining (immunohistochemistry): granulocytic sarcoma
Negative staining (enzyme cytochemistry): lymphocytes, ALL
Enzyme cytochemistry for myeloperoxidase (not immunohistochemistry) is the most sensitive and specific stain for myeloid leukemias and granulocytic sarcoma
Stains neutrophils strongly (diffuse granular pattern), other granulocytes variably
Positive staining (enzyme cytochemistry): neutrophils, eosinophils, monocytes (variable), AML-M1, M2, microgranular M3
Positive staining (immunohistochemistry): granulocytic sarcoma
Negative staining (enzyme cytochemistry): lymphocytes, ALL
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